Phenolic derivatives from heartwood of Cryptocarya pulchrinervia (Lauraceae)
Abstract
Cryptocarya is a genus of plants in the Lauraceae family with 350 species. This genus has many economic values, such as building materials, perfume, and traditional medicines. Cryptocarya were reported to contain flavonoids, pyrones, and alkaloids as main secondary metabolites, as well as phenyl propanoids, lignans, stilbenoids, terpenoids, and steroids. Isolation and bioactivity of secondary metabolites of C. pulchrinervia leaves have been recently reported. Meanwhile, the isolation of other plant parts, such as the heartwood, has never been conducted. Therefore, the objective of this research was to isolate secondary metabolites from the heartwood of C. pulchrinervia and determine their bioactivity against murine leukemia P-388 cells. The structures of the isolated compounds were determined based on 1D-NMR spectroscopy data (1H-NMR and 13C-NMR). In this research, three secondary metabolites were isolated, consisting of three phenolic compounds, i.e., syringaldehyde (1), coniferaldehyde (2), and sinapaldehyde (3). The IC50 values of the extract and the compound 1-3 was 57.91 mg/mL, 28.0 mg/mL, 26.47 mg/mL, and 24.00 mg/mL, respectively. The extract and all compounds were inactive against P-388 cells.
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